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Similarly, diabetes is an independent risk factor associated with increased risk of postoperative complications, prolonged hospitalisation and postoperative mortality [25]

Calcium Channel Blockers (CCBs) Mechanism: Block L-type calcium channels vascular smooth muscle relaxation peripheral resistance Types & Examples: Dihydropyridines: Amlodipine, Nifedipine more vasodilatory Non-dihydropyridines: Verapamil, Diltiazem also heart rate Key Points: Good for isolated systolic hypertension, angina 4

CO can selectively impede the functioning of TNF-, IL-1 and macrophage inflammatory proteins, which are pro-inflammatory cytokines, triggered by LPS [57, 58]

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