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[PubMed] 118

Correcting the deficiency alone can stabilise mood, sleep, and overall well-being, even without specific withdrawal medication

Calogero AE, Gullo G, La Vignera S, Condorelli RA, Vaiarelli A

7 , 303ra137 (2015)

In DKD, continuous activation of RAAS leads to elevated pressure within the glomeruli, enhances the production of ROS, promotes tissue damage, triggers the release of proinflammatory cytokines, and stimulates the development of fibrosis in the glomeruli and tubulointerstitium