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Moyer A, Salavaggione O, Hebbring S, Moon I, Hildebrandt MA , Eckloff B, Schaid D, Wieben E, Weinshilboum R

It supports the biosynthesis of acetylcholine, which is the most abundant neurotransmitter in the body, regulating activities of vital organs and blood vessels, and the communication between nerves and muscles.*

Recent findings intriguingly suggest that OPTN plays a role in the senescence of renal tubular epithelial cells when exposed to elevated glucose levels (Xiao et al., 2017)

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There is now growing appreciation that renal impairment can develop in people with diabetes in the absence of increasing albuminuria and in the presence of other nondiabetes-related causes of CKD