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doi: 10.3390/jcm10143028 [PubMed] 34618762 Rosenthal ES

10.1007/s11095-015-1652-z 19 LiuJ.QuanJ.FengJ.ZhangQ.XuY.LiuJ.et al (2016)

Research on discontinuation: SURMOUNT-4 trial examined what happened when people stopped tirzepatide after losing weight Participants regained approximately two-thirds of the weight they had lost within 1 year of stopping Appetite suppression effects end within weeks of the last injection Metabolic adaptations (slower metabolism from weight loss) persist Why regain happens: Medication suppressed appetite