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The mean age of the entire cohort was 71.3 9.6 years, with no statistically significant difference between Sequence 1 (HA-first) (68.1 10.2 years) and Sequence 2 (GSH-C4-first) (74.5 8.4 years) (p = 0.2898)
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This receptor activation results in: Rapid, pulsatile increases in GH secretion Amplification of sleep-related GH peaks Synergistic interaction with Growth Hormone-Releasing Hormone (GHRH) pathways The end result is elevated circulating levels of GH and IGF-1 , which support muscle growth, fat metabolism, and tissue repair