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The efferocytosis of apoptotic cells infected with Escherichia coli , in vitro, activates TLR4/TRIF and Myd88 and induces TGF-, IL-6, and IL-23 production by dendritic cells, leading to the differentiation of IL-17A lymphocytes

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INTRODUCTION Despite being considered one the safest pharmaceuticals, paracetamol/acetaminophen (N-acetyl-p-aminophenol, APAP) overdose is one of the most important causes of drug-induced liver injury, that can eventually lead to acute liver failure (ALF) ( 1, 2 )