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To evaluate the contribution of CA9 to the medicinal efficacy of ATT-I, an adeno-associated virus 9 (AAV9) carrying a mouse CA9-specific short hairpin RNA (shRNA) was constructed and used for in vivo gene silencing

Rather, current data suggest fomepizole inhibits the kinase activity of pJNK, itself, stopping the phosphorylation of Sab, and interrupting the amplified cycle, eventually leading to restoration of inactivated JNK

[PubMed: 30362276] 63