Additionally, it has been shown to modulate the serotonergic and dopaminergic systems within the brain
38 The SUMMIT trial (tirzepatide versus placebo in patients with HFpEF and obesity) produced similar results (NCT04847557)
Peptide with 99% purity (assassed by high pressure liquid chromatography, HPLC, with the biologically inactive 1-des-Gly peptide as the impurity) was used
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The study found that all efpeglenatide dosages notably decreased body weight, showing reductions between 6.3 and 7.2 kg compared to the placebo