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While these promising results in the rat model cannot be directly extrapolated to humans, they nonetheless lay a scientific foundation for future translational research and clinical trials to explore combinatorial strategies addressing both metabolic and neurodegenerative complications of diabetes

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Auditory learning and memory were assessed using the Auditory Verbal Learning Test - Chinese version (ALVT) 27 , attention was assessed using the Symbol Digit Modalities Test (SDMT) 28 , working memory was assessed using the Stroop Color-Word Interference Test (Stroop) 29 , and visuospatial memory was assessed using the Rey-Osterrieth Complex Figure Test (RCFT) 30

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