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This dual-action approach (reduced intake + increased expenditure) may explain two notable findings from retatrutide clinical trials: greater magnitude of weight reduction achieved in shorter timeframes (24.2% at 48 weeks vs

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From a practical standpoint, the most defensible position remains planned exposure avoidance: explicit fertility planning, reliable contraception during treatment, label-informed discontinuation before conception attempts, immediate cessation once pregnancy is recognized, and active metabolic maintenance during the washout period to reduce rebound-related gestational risk (132137)

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