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In further research, it was found that the neuroprotection mediated by berberine after ischemia involves the AKT/glycogen synthase kinase-3 (GSK3)/extracellular signal-regulated kinase 1/2 (ERK 1/2) signal pathway, and inhibits Jun amino-terminal kinases (JNK) and caspase-3 activity (Simes Pires et al., 2014)

If needed, the capsules can also be opened and the contents stirred into water or another beverage

endothelin and angiotensinogen, as well as a lower estrogen to androgen ratio during the menopause [40]

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doi:10.1152/physrev.1983.63.4.1420