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Ethical approval statement: This study was conducted in strict accordance with the guidelines of the Institutional Animal Care and Utilization Committee of Nanjing Agricultural University

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During the first few weeks of using tretinoin, acne may appear worse as the medication works on pimples from the inside out

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If you couldn't administer it as scheduled or forgot, administer it immediately if there are 3 days (72 hours) or more until the next scheduled administration date, and then administer the next dose on your regular day