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Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells

Nasal DPI Peptides for CNS Therapy/Disease Application The IN delivery of proteins and peptides to the CNS allows for the treatment of neurodegenerative diseases such as AD [103], PD [104,105,106], and multiple sclerosis [107,108], among others

This increase in volume allows bulkier ligands to enter the pocket, and this may induce AR promiscuity for other hormones and analogs, such as estrogens and progesterone

Complement-targeting therapeutics for ischemia-reperfusion injury in transplantation and the potential for ex vivo delivery

W.et al (2023)