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Severe allergic reactionssuch as difficulty breathing, rash, or swelling of the face and throatare extremely rare but require immediate medical attention

[4] Based on animal research, it is thought that the increased methylmalonyl-CoA hydrolyzes to form methylmalonate (methylmalonic acid), a neurotoxic dicarboxylic acid, causing neurological deterioration

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The typical way to get the recommended daily amount of B12 is to consume it as part of your everyday diet

For the broader budget framework, see Peptide Research Budgeting and The NAD+ Research Budget