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Melatonin receptor polymorphisms (notably MTNR1B variants) are linked with impaired insulin secretion and heightened diabetes risk, suggesting receptor-level modulation of insulin homeostasis (198)

PMID 16496488

Why that matters: cortisol and GLP-1 effectiveness are inversely linked, and perimenopausal estrogen decline dysregulates the HPA axis, raising baseline cortisol and driving hormonal belly fat redistribution that keeps women stuck at a normal BMI with real metabolic dysfunction

Features of pigmented vulval lesions on dermoscopy