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Moreover, exposing mice to a low dose which reflects a typical American diet (0.01 mg/kg/day), caused gut microbiota alterations across two generations-consistent with earlier findings, Akkermansia muciniphila was depleted, while ParaBacteroides distasonis and Christensenellaceae were elevated in the second generation ( ParaBacteroides responses appear to vary between studies, as Buchenauer et al

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66 Another analysis reported sustained weight loss for up to 4 years in participants who continued treatment

10.3906/tar-1206-29 71 OkumuM.MbariaJ.KanjaL.GakuyaD.KiamaS.OcholaF.et al (2016)