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Many of these relate to tissue remodeling, antioxidant response, and anti-inflammatory pathways
The injection of dietary Se allows rapid recovery of a saturable activity of GPx1
Above mentioned therapies may resolve neurological deficits and reduce pain (although in many cases insufficient), but they do not lead to repair of the degenerated IVD
The modified drug would need to remain active 24 h/d, be as or more potent than native GLP-1, and remain physically stable for long periods of time
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