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GIP receptor activation at low doses supports mitochondrial function in adipose tissue and may contribute to improved fatty acid metabolism independent of the dramatic appetite suppression seen at full doses

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Jord MA, Verbakel SE, Valk PJ, Vankan-Berkhoudt YV, Maccarrone M, Finazzi-Agr A, Lwenberg B, Delwel R

When taken orally, peptides are rapidly broken down by digestive enzymes in the stomach and small intestine before they can be absorbed into the bloodstream in meaningful quantities