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REDEFINE 1 was a 68-week, double-blind, placebo- and active-controlled efficacy and safety phase 3 trial of once-weekly CagriSema, cagrilintide 2.4 mg and semaglutide 2.4 mg versus placebo in 3,417 adults with obesity or overweight with one or more comorbidities and without type 2 diabetes

Different ligands may trigger different conformational changes and activate different downstream signals

It has been used for short-term weight management for over 60 years and typically produces results over 12 weeks

Mar Drugs 17(10):567

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