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Despite the high sensitivity and negative predictive value of S100B in detecting traumatic intracranial hemorrhage, our review indicates that S100B has not been utilized as an efficacy indicator in animal acupuncture intervention models of TBI

The first wave of disruption is caused by a sudden loss of blood flow to the brain which can quickly lead to metabolic disturbances, inflammation, oxidative stress, and neuronal death, while the second wave occurs at the reperfusion of oxygenated blood into the affected area, putting oxidative stress on the system

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1 Owing to their rarity, most of the existing knowledge about MMNSTs comes from individual case reports or small case series