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To interrogate whether melatonin could restrain ILC2 effector function we employed an adoptive transfer model, whereby activated ILC2s were isolated from Rag2 -/- mice, cultured for 24h in the presence or absence of melatonin, and then adoptively transferred the ILC2s into Rag2 -/- GC -/- mice utilizing established protocol as described by our group previously (48, 49) ( Figure 4A )

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Selenoprotein H is a nucleolar thioredoxin-like protein with a unique expression pattern

For anemic patients or patients with autoimmune conditions, it is common to start off with one injection per week for six weeks, before beginning a monthly maintenance dosage