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Keleku-Lukwete N, Suzuki M, Yamamoto M

Contributing factors include: A diet high in sugar and processed fats[1] Exposure to environmental toxins like air pollution, pesticides and heavy metals[2] Cigarette smoke[3] and alcohol use[4] Infections and chronic inflammation[5] Intense or prolonged physical exertion[6] Psychological stress[7] Biochemically, oxidative stress is marked by an imbalance between oxidants and antioxidants, disrupting cellular signaling, promoting inflammation and weakening mitochondrial function.[8] Over time, this imbalance can lead to cumulative molecular damage, a foundational factor in aging and disease progression

Bioscience Reports, May 2021, ePublication 3

Endoplasmic reticulum stress and type 2 diabetes

J Clin Endocrinol Metab 2007