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Some of the studies about the influence of mentioned minerals on DS individuals are presented in Table 3

Individuals taking metformin alongside Mounjaro face increased risk of B12 deficiency, as metformin is known to impair B12 absorption, and may require more frequent monitoring

Insurance Barriers: May not cover for weight loss (only approved for diabetes) Requires type 2 diabetes diagnosis for coverage Extensive prior authorization requirements May require trying other medications first High copays even with coverage Supply Shortages: Both Mounjaro and Zepbound have experienced periodic shortages since launch, making consistent access difficult

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Average weight loss in trials: about 15% on Wegovy (semaglutide), 20% on Zepbound (tirzepatide), 8% on Saxenda (liraglutide)