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Allopurinol-induced hypersensitivity syndrome, characterized by exfoliative dermatitis and liver failure, arises from purine metabolism inhibition ( 3.5.2 Inadequate precision in metabolic regulation Emerging evidence highlights the multi-organ (hepaticrenalintestinal) coordination of urate metabolism, yet existing pharmacotherapies predominantly target single nodes (e.g., XO or URAT1)

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