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Understanding this changes how you think about dosing, side effects, and what happens if you stop taking it

1 , 41 It is unclear if retatrutide modulates energy expenditure or attenuates metabolic adaptation in humans, though retatrutide has been found to maintain energy expenditure during weight loss in animal models, and this may be due to its effects on the glucagon receptor

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Its safety profile is similar to existing incretin-based therapies, making it a particularly promising candidate for obesity, type 2 diabetes, and related metabolic conditions

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