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At therapeutic doses, the liver's capacity is often saturated

This disrupts appetite suppression and metabolic signaling, often triggering hunger spikes, nausea during rebound periods, and uneven weight loss

Zepbound vs Wegovy Weight Loss Results Zepbound has demonstrated greater average weight loss in clinical trials compared to Wegovy: Zepbound led to as much as a 20.9% average reduction in body weight at the highest 15 mg dose over 72 weeks, according to results from the SURMOUNT-1 trial