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That includes $38.8 billion in direct costs of covering AOMs as well as $3.4 billion in savings from improved health

The GLP-1 receptor is a type of cell surface receptor that binds to GLP-1, triggering a signaling cascade that leads to various effects, including the stimulation of insulin secretion, the inhibition of gastric emptying, and the promotion of satiety

Brown JC, Dryburgh JR

GLP-1s are generally well tolerated, with most gastrointestinal side effects subsiding over time

To stay ahead of this shifting environment, pharma companies should consider the following imperatives: Massive patient drop-off undermines obesity GLP-1 uptake: Despite strong demand, only 10% of obesity patients persist with therapy after one year