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A randomized phase 2 study with exploratory biomarker analysis of ficlatuzumab, a humanized hepatocyte growth factor (HGF) inhibitory monoclonal antibody, in combination with gefitinib versus gefitinib alone in Asian patients with lung adenocarcinoma

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This analysis implies that, at pH 6.87 the 50% of the low solubility acid determines the total amount of niclosamide in solution, i.e., from Eqn 4, the other 50% of niclosamide is the highly soluble deprotonated salt that matches the amount of the low solubility acid in solution

Administration should never be considered routine or risk-free

FDA-Approved Drugs An FDA-approved drug has undergone an agency review of a specific product for defined uses, manufacturing controls, labeling, and an evidence package intended to support safety and effectiveness