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For diabetes, this typically means trying metformin first

doi: 10.1186/s12888-016-1049-5

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The GLP-1-producing preproglucagon (PPG) neurons located in the nucleus tractus solitarius (NTS) and the intermediate reticular nucleus of the medulla oblongata are the major source of endogenous GLP-1 in the central nervous system, which project widely throughout the central nervous system especially the autonomic control areas (Merchenthaler et al., 1999

Medical supervision ensures appropriate dosing, ongoing monitoring, and a personalized plan that considers a patients full medical history