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Same active ingredient, different FDA indications, different coverage logic

Our research method We began our research by gathering June and July 2025 entries for semaglutide, tirzepatide, pembrolizumab, and antibiotics in the FDAs Imports Entry Data Search (1)

INTRODUCTION The glucagon-like peptide-1 receptor (GLP-1R) is widely expressed in many tissues and mediates the action of the gastrointestinal peptide hormone, glucagon-like peptide-1 (GLP-1) 1

Dapagliflozin is a weak substrate of the P-glycoprotein (P-gp) active transporter, and dapagliflozin 3-O-glucuronide is a substrate for the OAT3 active transporter

Biochem Biophys Acta