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These trials underscore that the latest generation of diabetes therapies is as much about protecting the heart and kidneys as controlling glucose

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Further, GLP-1RAs promote VSMC redifferentiation via AMPK/SIRT1/forkhead box O (FOXO3a) pathways, where the expression of contractile VSMCs markers (SM22 and Calponin) is increased [125]

(10) While more research is needed to help us understand exactly what these effects are, one thing we do know is that intermittent fasting offers many of the same benefits as GLP-1 when it comes to supporting metabolism, blood sugar control, and weight loss