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There is currently no evidence showing that microdosing tirzepatide works better than standard dosing
Lancet 359:20532058 Belch J, Hiatt WR, Baumgartner I, Driver IV, Nikol S, Norgren L, Van Belle E, Committees T, Investigators (2011) Effect of fibroblast growth factor NV1FGF on amputation and death: a randomised placebo-controlled trial of gene therapy in critical limb ischaemia
It mimics both GLP-1 and glucose-dependent insulinotropic polypeptide (GIP), enhancing insulin secretion while reducing glucagon production
Alternatives include dietitian-led dietary modification, tailored physical activity programmes designed by physiotherapists experienced in neuromuscular conditions, psychological support, and consideration of other pharmacological options such as orlistat