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Despite an initial severe presentation, she has had normal intellectual development and few complications of her disorder with a treatment regimen that includes polycitra (citric acid, potassium citrate and sodium citrate), vitamin C, vitamin E and selenium

Under specific conditions of glucose or amino acid starvation, autophagy is compensatory to participate in the basic metabolic cycle of cells by acting on intracellular proteins, lipids, and other organic macromolecules ( Autophagy in apoptosis Cells can undergo apoptosis in response to intracellular signaling, extracellular signaling, and endoplasmic reticulum (ER) stress ( Figure 4 )

Trimarco V, Izzo R, Lombardi A, Coppola A, Fiorentino G, Santulli G (2023) Beneficial effects of L-Arginine in patients hospitalized for COVID-19: new insights from a randomized clinical trial

*Correspondence: Mercedes Bermdez, [email protected]

Last clinically reviewed: February 2026