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Sermorelin and Bupropion Interaction: Safety, Mechanisms, and Clinical Guidance At a glance Interaction severity / low (no shared metabolic pathway) Sermorelin clearance / peptidase-mediated, not CYP-dependent Bupropion metabolism / primarily CYP2B6, with CYP2D6 inhibition Seizure risk with bupropion / dose-dependent, 0.4% at 450 mg/day IGF-1 monitoring interval / every 4 to 6 weeks after initiation Fasting glucose check / recommended within 30 days of co-prescribing GH peak after sermorelin / 60 to 90 minutes post-injection Bupropion half-life / 21 hours (hydroxybupropion active metabolite) FDA sermorelin status / previously approved, now available via 503A compounding Evidence level for this combination / no published case reports of adverse interaction Why This Drug Pair Gets Flagged Patients prescribed sermorelin for growth hormone optimization and bupropion for depression or smoking cessation frequently ask whether the two medications conflict
To study chronic IGF-1 elevation over several days without repeated administrations: CJC-1295 with DAC (GHRH analog, 8-day half-life, IGF-1 up to 28 days in multidose)
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