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For example, in in vitro studies, shRNA is often used to silence the expression of metabolic enzymes to observe their effects on ammonia metabolism, whereas in vivo , the affected sites may be more numerous and complex

doi: 10.1373/clinchem.2010.150631

In this particular study, the researchers performed surgery on rats, removing a different organ from each rodent in an attempt to better understand which organ systems BPC-157 interacts with outside of the stomach