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B12 acts as a cofactor for two important enzymes: methionine synthase, which is involved in DNA production and methylation processes, and methylmalonyl-CoA mutase, which is essential for fatty acid metabolism and energy production

Although treatment is associated with short-term side effects, such as decreased appetite [46], weight loss, headaches, anxiety [13,46], and sleep problems [47], it also has long-term effects, such as impacting bone health [46,48]

The medications used in MAT can provide relief from the challenging symptoms and cravings associated with opioid withdrawal, making it easier for people to function in daily life and in treatment

This page treats both formats as research-context references, not personal use guidance