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Uricase-deficient larval zebrafish with elevated urate levels demonstrate suppressed acute inflammatory response to monosodium urate crystals and prolonged crystal persistence

P., Henry K., OHearn M., Montaner J

The side effects are real annoying at best and debilitating at worst and can include nausea, diarrhea, cramps and abdominal pain, constipation, vomiting, gastroesophageal reflux, gastroenteritis, pancreatitis, gastroparesis, intestinal obstruction, gall bladder disease, headaches and potential risk for certain types of thyroid and endocrine cancers, among other adverse effects

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