Existing and old CNS drugs in the market has many side effects and associated with weight gains in patients
Alternatively, continued regulatory restriction could push more research into countries with more permissive frameworks, potentially fragmenting the evidence base geographically
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The side effects are real annoying at best and debilitating at worst and can include nausea, diarrhea, cramps and abdominal pain, constipation, vomiting, gastroesophageal reflux, gastroenteritis, pancreatitis, gastroparesis, intestinal obstruction, gall bladder disease, headaches and potential risk for certain types of thyroid and endocrine cancers, among other adverse effects
Additional rating scalespecific diagnostics (eg., leave-one-out analyses and small-study effect assessments) are provided in the Supplement