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While the mechanism is not fully understood, the theory involves sustained hormonal stimulation of pancreatic cells potentially triggering inflammatory cascades in susceptible individuals

Tingling and numbness : B12 is essential for nerve function

Upon loss of microbial signals, modeled by germ-free, gnotobiotic, and broad-spectrum antibiotic-treated rodents, eEANs sensed the changes in intestinal epithelial and mucosal areas in the lamina propria, relayed signals to sensory vagal afferents of the nodose ganglion and dorsal vagal complex, sympathetically activated glutaminergic neurons lateral to the paragigantocellular nucleus/rostral ventrolateral medulla (LPGi/RVLM) and downstream coeliac-superior mesenteric ganglia (CM-SMG), whereby efferent nerves reduced GI transit time

Demonstrates collagen stimulation and skin improvement at 1-2mg daily doses n.d

However, Vitamin B12 is not always adequately absorbed by the body in the digestion process, thus creating a deficiency