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As potent antioxidants, omega-3 PUFAs upregulate Nrf2, mitogen-activated protein kinase (MAPK) phosphatases, GSH and HO-1 genes

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Significant reductions in serum levels of total IS, p-CS, IL-6, and malondialdehyde (as markers of inflammation and oxidative stress, respectively) were observed in 30 patients with ESKD undergoing hemodialysis treatment after an 8-week administration of synbiotics containing 2 10 11 (CFU)/g of Lactobacillus acidophilus La-14 and FOS (Kuskunov et al., 2023)

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