glp 1 and gallbladder disease GLP-1 Risk: What Clinicians Should Watch Gallstones and Semaglutide: Safety Guide

Siga sempre a orientao do seu profissional de sade

doi: 10.3390/ijms23063110 405 GanJZhangXMaCSunLFengYHeZet al

My Approach When Prescribing Here's my general framework not a rigid protocol, but a starting point for the conversation: I Tend to Start with Semaglutide When The patient has established cardiovascular disease (because of the SELECT trial data) Insurance covers semaglutide but not tirzepatide The patient has MASH/fatty liver disease Cost is the primary concern and semaglutide is more accessible I Tend to Start with Tirzepatide When Maximum weight loss is the primary goal The patient has type 2 diabetes (tirzepatide shows greater A1C reduction roughly 2.02.5% vs 1.02.0% for semaglutide) The patient has tried semaglutide with insufficient results Insurance covers both options equally Regardless of which medication we choose, I always emphasize that GLP-1 therapy is most effective when combined with nutritional counseling, physical activity, and behavioral support

The most important message to get across is that these are products which are not approved for human use, and the risks are much more likely to outweigh the benefits, she says

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