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Most were not designed to evaluate long-term outcomes in children exposed to these medications in-utero

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Effect of Berberine on the Levels of Sex Hormones in Polycystic Ovary Syndrome-Induced by Letrozole in Adult Female Wistar Rats

It wasn't randomized, and the women who took the drugs were different from the ones who didn't: better educated, more affluent and with some indicators of better mental health