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Additionally, Pernicious anemia, an autoimmune condition affecting the stomachs ability to produce intrinsic factor (a protein necessary for B12 absorption), can also lead to deficiency

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Vaisman-Mentesh A, Gutierrez-Gonzalez M, DeKosky BJ, Wine Y

Both these methylation reactions are vital for growth and cell reproduction.[9][10] Methionine, a sulfur-containing, essential amino acid, is a precursor of S-adenosylmethionine, a cofactor for one-carbon metabolism and the final methyl donor for the methylation of DNA, RNA, proteins, and phospholipids.[11] The methionine synthase plays a paramount role in the synthesis of nitrogenous bases (purines and pyrimidines) involved in the formation of DNA