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The 30-day rule applies whether the pen is opened or unopened, so there's no benefit to keeping a pen sealed if it's already been out of the fridge

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[8] Novo Nordisk announced late at the 2025 European Association for the Study of Diabetes (EASD) annual meeting that in the REDEFINE 1 study, [9] cagrilintide provided clinically significant weight loss, with a mean reduction in body weight of 11.8% compared to 2.3% with placebo after 68 weeks, considering adherence of all participants to treatment

The authors identified future areas of investigation including male models, long-term treatment effects, and combination with other NAD+ precursors such as NMN

Many comments suggested CMS could modify the methodology used when determining the cost threshold for a code combination to qualify for a complexity adjustment