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Particularly concerning is the risk of dementia with chronic use, a correlation supported by multiple epidemiological studies

Higher-risk situations may include: Older age Existing sarcopenia or frailty Recent falls Difficulty rising from a chair Low baseline physical activity Very low protein or calorie intake Rapid or excessive appetite suppression Chronic kidney, liver, pulmonary, or cardiovascular disease Cancer or another catabolic illness Recent hospitalization Significant gastrointestinal adverse effects Very rapid weight loss Inability to participate in resistance exercise These factors do not automatically make GLP-1 therapy inappropriate

GHK-Cu is well-tolerated and easily incorporated into hair products such as creams and serums that may be applied directly to the scalp

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