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Berberine Action: Improves insulin sensitivity, regulates blood sugar, supports gut microbiota indirectly stimulates GLP-1 Dosage: 500 mg 2-3 times a day (before meals) Efficacy: Equivalent to metformin (a diabetes medication) in some studies 2

No other differences were observed in bacterial groups

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Dose-finding study of subcutaneously administered BI 456906 for 16 weeks, compared with placebo and open-label semaglutide in patients with type 2 diabetes mellitus