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Since 2023, the approval and commercialization of the oral version of semaglutide, Rybelsus, has been closely watched

A 2021 study published in Nature Microbiology identified a protein called P9, secreted by Akkermansia muciniphila, that was sufficient to induce GLP-1 secretion and brown adipose tissue thermogenesis in mice on a high-fat diet

Semaglutide stands as a beacon of innovation in the pharmacological management of type 2 diabetes and obesity, marking a significant advancement in our approach to these pervasive health challenges

Methodologies, limitations, and additional citations are also available on MedRxiv and directly within Truveta Studio.

Doctors may recommend these medications off-label for weight management if lifestyle changes alone are not enough