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AKT then promotes protein synthesis by activating the mTOR pathway, a crucial regulator of cell growth and protein synthesis

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We need to move our thinking to getting people on these guideline-directed therapies that improve substantial outcomes like death at an early stage. Pantalone said first-line therapy may become individualized for each patient, with SGLT2 inhibitors being used for some people with CKD and semaglutide being prescribed to others

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