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Biochem Biophys Res Commun 530(3):494499

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Bariatric and upper gastrointestinal surgery exerts profound improvements in glucose metabolism and can even induce remission of type 2 diabetes (T2D) (1, 2), thus demonstrating the importance of the gastrointestinal tract as a key regulator of systemic glucose metabolism

Real-world effectiveness Studies examining real-world outcomes show that results are typically somewhat lower than in clinical trials but still significant: A 2025 Cleveland Clinic study found average weight loss of 10-15% in routine clinical practice (compared to 15-22% in trials)