These include not only GLP-1 but also insulin, leptin (which is made by and regulates adipose tissue), and grehlin , known as the hunger hormone which, when suppressed, switches off the impetus to eat
Problematic chronic inflammation: Sustained inflammation (lasting weeks to months) degrades healthy tissue through proteolytic enzymes, reactive oxygen species, inflammatory cytokines (IL-1, TNF-)
Future research should focus on these aspects to ensure the sustained safety and efficacy of tirzepatide in clinical applications
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